Post by Admin/ Traveler on Jan 3, 2019 20:39:00 GMT
Serum carnitine concentration is decreased in patients with Lyme borreliosis
"Abstract
BACKGROUND:
Lyme borreliosis (LB) is a serious infectious disease. Carnitine plays a crucial role in metabolism and inflammatory responses. Carnitine may be important in improving neuronal dysfunction and loss of neurons.
AIM:
To evaluate serum carnitine concentration in adult patients with various clinical types of LB.
MATERIAL/METHODS:
Groups: 1) patients with erythema migrans (EM, n=16), 2) neuroborreliosis (NB, n=10), 3) post-Lyme disease (PLD, n=22) and healthy controls (HC, n=32). Total (TC) and free (FC) carnitine were determined with the spectrophotometric method.
RESULTS:
TC levels (44.9±10.4, 28.0±8.4, 35.9±15.6 μmol/L) in the EM, NB and PLD patients were lower than in HC (54.0±11.4 μmol/L), p < 0.001. FC levels (32.7±7.7, 23.6±6.8, 26.3±11.2 μmol/L) in the EM, NB and PLD patients were lower than in HC (40.5±7.6 μmol/L), p < 0.001. AC levels (12.2±5.2, 4.4±2.6, 9.6±7.4 μmol/L) in the EM, NB and PLD patients were lower in the NB and PLD patients than in HC (13.5±8.40 μmol/L), p <0.001. AC/FC ratio was 0.31±0.14, 0.18±0.09, 0.39±0.33 in the EM, NB and PLD patients.
CONCLUSIONS:
LB patients exhibit a significant decrease of their serum carnitine concentrations. The largest changes were in the NB and PLD patients. To prevent late complications of the disease a possibility of early supplementation with carnitine should be considered. Further studies are required to explain the pathophysiological significance of our findings."
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So, Trav here. If you are like me, after reading this, you'll think, "okay, so now what? Do I have the symptoms of this? And then, what if I do?"
So, here is a couple of article to help you determine the symptoms of low carnitine and if you have need of learning more:
Carnitine Deficiency
Linus Pauling Institute - L-Carnitine
This last article lists the foods and the amount each provides of carnitine, as well as the supplementation dosages, if you should need them.
If nothing else has helped, it might be worth checking into this to see if it will help you!
"Abstract
BACKGROUND:
Lyme borreliosis (LB) is a serious infectious disease. Carnitine plays a crucial role in metabolism and inflammatory responses. Carnitine may be important in improving neuronal dysfunction and loss of neurons.
AIM:
To evaluate serum carnitine concentration in adult patients with various clinical types of LB.
MATERIAL/METHODS:
Groups: 1) patients with erythema migrans (EM, n=16), 2) neuroborreliosis (NB, n=10), 3) post-Lyme disease (PLD, n=22) and healthy controls (HC, n=32). Total (TC) and free (FC) carnitine were determined with the spectrophotometric method.
RESULTS:
TC levels (44.9±10.4, 28.0±8.4, 35.9±15.6 μmol/L) in the EM, NB and PLD patients were lower than in HC (54.0±11.4 μmol/L), p < 0.001. FC levels (32.7±7.7, 23.6±6.8, 26.3±11.2 μmol/L) in the EM, NB and PLD patients were lower than in HC (40.5±7.6 μmol/L), p < 0.001. AC levels (12.2±5.2, 4.4±2.6, 9.6±7.4 μmol/L) in the EM, NB and PLD patients were lower in the NB and PLD patients than in HC (13.5±8.40 μmol/L), p <0.001. AC/FC ratio was 0.31±0.14, 0.18±0.09, 0.39±0.33 in the EM, NB and PLD patients.
CONCLUSIONS:
LB patients exhibit a significant decrease of their serum carnitine concentrations. The largest changes were in the NB and PLD patients. To prevent late complications of the disease a possibility of early supplementation with carnitine should be considered. Further studies are required to explain the pathophysiological significance of our findings."
---------------------------------------------------------------------------------------------------------------------
So, Trav here. If you are like me, after reading this, you'll think, "okay, so now what? Do I have the symptoms of this? And then, what if I do?"
So, here is a couple of article to help you determine the symptoms of low carnitine and if you have need of learning more:
Carnitine Deficiency
Linus Pauling Institute - L-Carnitine
This last article lists the foods and the amount each provides of carnitine, as well as the supplementation dosages, if you should need them.
If nothing else has helped, it might be worth checking into this to see if it will help you!